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KMID : 0360220080490101649
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 10 p.1649 ~ p.1657
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The Antimydriatic Effect of Brimonidine 0.15% on the Dark-adapted Pupil in Dark Brown Irides
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Rho Seung-Soo
Lew Ho-Min
Yang Hong-Seok
Ahn Jae-Hong
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Abstract
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Purpose: To analyze the effect of the daily use of brimonidine tartrate 0.15% on the dark-adapted pupil diameter in dark brown irides.
Methods: Twenty-five healthy volunteers administered brimonidine tartrate 0.15% to their right eyes once daily for 3 weeks. Infrared digital photographs of the pupil were taken before administration and 1 hour and 4 hours after administration after dark adaptation (at <0.1 lux ambient illumination for 5 minutes). The diameters of both pupils were measured on the first day, on administration days 7 and 21, and on washout day 7.
Results: Four hours after the first administration, pupils showed a decrease of 0.95±0.74 mm, 1.03±0.94 mm, 0.61±0.85 mm on the first day, administration day 7, and administration day 21, respectively (p<0.01), compared with baseline data. The anti-mydriatic effect of brimonidine was sustained for 3 weeks, but the proportions of the eyes showing a reduction in pupil diameter by 0.5 mm or more were 84%, 76%, 68%, and 52% at 4 hours on the first day, administration days 7 and 21, and washout day 7, respectively.
Conclusions: The anti-mydriatic effect of the daily use of brimonidine 0.15% on dark brown irides in a scotopic condition is maintained during the instillation period but has a tendency to fade over time. This point should be considered when using this compound as a miotic agent.
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KEYWORD
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Anti-mydriatic effect, Brimonidine tartrate 0.15%, Brown iris, Dark-adapted pupil
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